NanoGagliato is a first-of-its-kind scientific conference merging intense but informal discussion, STEM education for youths, technological problem-solving, artistic expression, and a solid dose of fun and exploration in vibrant southern Italian coastal communities. What began in 2008 as a gathering of friends and nanoscience experts has transformed into an annual celebration bringing together scientists, physicians, humanitarians, communicators, government leaders, venture capitalists, and of course, the people of Gagliato and its surrounding communities, for five-days of scientific exchange, dissemination and education. NanoGagliato remains anchored to its nanoscience roots, with each conference exploring new facets of the question, how can nanoscience – especially nanomedicine – help solve our world’s most pressing problems?